منابع مشابه
Evaluation of Thyroid Autoantibodies in Type 2 Diabetes
OBJECTIVE: Diabetes mellitus and thyroid disease are the two common endocrinopathies seen in adult population. Studies to evaluate thyroid disorders in patients with type 2 diabetes are lacking. The aim of this study was to compare prevalence of thyroid dysfunction and autoim-munity in type 2 diabetic patients with age and sex matched non-diabetic control group. MATERIAL AND METHODS: Among pat...
متن کاملAutoantibodies in diabetes.
Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The appearance of autoantibodies to one or several of the autoantigens-GAD65, IA-2, or insulin-signals an autoimmune pathogenesis of beta-cell killing. A beta-cell attack may be best reflected by the emergence of autoantibodies dependent on the genotype risk factors, isotype, and subtype of the autoantibo...
متن کاملDiabetes-related autoantibodies and gestational diabetes.
HETEROGENEITY OF AUTOIMMUNE DIABETES: AN OVERVIEW — Autoimmune diabetes is caused by the destruction of -cells of pancreatic islets by an immune-mediated process, promoted by the interaction of genetic and environmental factors (4). Autoantibodies (AAs) against pancreatic -cell antigens precede the clinical onset of type 1 diabetes (4). Circulating islet cell antibodies, originally described by...
متن کاملAnti-CD38 autoantibodies in type? diabetes.
Human diabetes mellitus comprises two main clinical entities: type 1 and type 2 diabetes. While type 1 diabetes is autoimmune in origin, type 2 diabetes is due to a decreased sensitivity to insulin action (so-called insulin resistance) associated with impaired beta cell function. However, it is becoming increasingly clear that there is a certain overlap between these two diseases. While some de...
متن کاملRole of autoantibodies in type 1 diabetes.
Type 1A, the immune mediated form of diabetes, is a relatively common disorder that develops in genetically susceptible individuals. The disease is associated with a series of anti-islet autoantibodies and the autoantibodies can be present for years prior to the onset of hyperglycemia. In general it is thought that type 1A diabetes is T cell mediated, but there is evidence from studies in the N...
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ژورنال
عنوان ژورنال: Pathology
سال: 2020
ISSN: 0031-3025
DOI: 10.1016/j.pathol.2020.01.165